The Day One Bet: Founders Who Hack Health And Longevity
Masha Bucher, Founder & General Partner at Day One Ventures, has a clear vision for the future of healthcare. "The best thing you can do is focus on your customers," she says. "Learn everything about them, and find insights no one else has. If you build around that, you'll always stay ahead."
Day One Ventures was launched in 2018 with a mission to bridge technology and society—through capital, art, storytelling, and culture. The fund backs early-stage founders with customer-obsessed DNA, accelerating the mass adoption of technologies that can solve some of humanity's most pressing problems.
"The goal is to find the biggest world-changing ideas possible," Bucher says. "We back young, mission-driven founders with unconventional experience but extreme dedication." Today, some of those founders are disrupting the health and biotech industries, shaping the future of medicine, longevity, and human potential.
Meet Max Marchione, Co-Founder of Superpower
Superpower is the world's first health super-app. Starting with the most comprehensive biomarker testing service on the market, Superpower aims to deliver proactive, preventative, and personalized healthcare for everyone.
"Most people know more about the menu at their local coffee shop than what's happening in their own bodies," says Max Marchione, Co-Founder of Superpower. "The idea is simple but ambitious: make $100,000-quality medical insights affordable and accessible."
Superpower recently dropped its price point to $199, offering consumers a single place to track all their health records.
Max on the Future of Healthcare
"Health is a tool for human enhancement," says Marchione. "What excites me most about the industry is not just its rapid innovation, but the fact that it's becoming increasingly accessible."
"The next few years will be about preventing disease rather than treating it," he adds.
Max on AI and Transparency
Marchione also sees a growing trust in AI over traditional health systems. "As patients become more skeptical of entrenched institutions, they are turning to technology to provide answers, transparency, and confidence in their care."
Meet Max Kauderer, Co-Founder and CEO of Yuzu Health
Yuzu is building the infrastructure to change the way employer healthcare is structured. The company aims to create an operating system for health insurers so businesses can offer plans that make sense and employees get better, more accessible care.
"If you want to do anything meaningful in healthcare, you have to rebuild the really boring plumbing parts before you can do the really cool, interesting pieces," says Kauderer. "The goal is to simplify the system and make it more efficient."
Max on the Future of Insurance
"I believe in tackling the root cause, not the symptoms," says Kauderer. "Health insurance used to be simple—built on trust between provider, patient, and payor—but over time, misaligned incentives created bad actors, and layers of complexity turned the system into a black box."
Meet Jake Adler, Founder of Pilgrim
Pilgrim is developing battlefield-ready biotech—a bold ambition matched by Adler's willingness to take risks.
"You know it when you see it," says Joshua Browder, one of Jake's first investors and the Founder and CEO of DoNotPay. "When I first spoke with Jake, it was clear he was a top one-percent founder."
Jake on the Future of Biotech
"I back a lot of young founders, and I typically look for proof early on that they know how to build and distribute a product," says Browder. "Jake has that instinct."
Jake on Translation
"The only thing I care about is translation," says Adler. "By that, I mean moving technology from the benchtop to the patient. With AI and large language models, we can build faster and get solutions to the people who need them sooner."
Masha Bucher's Vision for Health and AI
"I see huge potential in applying AI to the study of the brain and the balance of the human body," says Masha Bucher. "We still don't understand so much. The more we learn, the more we can extend human potential."
Buchner on Commure
"Commure is a rocket ship," says Bucher. "The company is building AI infrastructure for health systems, integrating with more than 60 electronic health records and powering millions of patient encounters."